High mobility group box 1蛋白
WebJul 13, 2024 · High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein that has been widely reported to play a pivotal role in the pathogenesis of hematopoietic malignancies. As a representative damage-associated molecular pattern (DAMP), HMGB1 normally exists inside cells but can be secreted into the extracellular … WebNov 7, 2013 · High-mobility group box 1 (HMGB1), as a member of the HMG family, has location-specific biological functions: within the nucleus as a DNA chaper-one, within the cytosol to sustain autophagy and outside the cell as a damage-associated molecular pattern (DAMP) molecule.
High mobility group box 1蛋白
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WebThe high mobility group protein B1 (HMGB1) is an abundant protein that binds to distorted and damaged DNA [112,113]. It is involved in diverse functions, including recognition of cytosolic DNA, regulation of chromatin structure, transcription and DNA repair. HMGB1 expression is upregulated in several tumors and tumor endothelium [114]. WebApr 1, 2008 · High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytes Authors Ju Ho Youn 1 , Young Joo Oh , Eun Sook Kim , Ji Eun Choi , Jeon-Soo Shin Affiliation
WebFeb 25, 2013 · 1. Introduction. High mobility group box 1 (HMGB1) was originally described 30 years ago as a nonhistone DNA-binding protein with high-electrophoretic mobility ( 1 ). It is present in the nucleus of almost all metazoans and plants, where it exerts structural and transcriptional activities ( 2 – 4 ). In addition to its role in the nucleus ... WebApr 4, 2024 · Currently, ICU management of SAE is mainly based on non-pharmacological support. Pre-clinical studies have described the role of the alarmin high mobility group …
WebHMGB1抗体详情 (hide) Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB) Mouse monoclonal antibody raised against a full length recombinant HMGB1. HMGB1 (AAH03378.1, 1 a.a. ~ 215 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. WebAnti-HMGA2 (high mobility group A2)高迁移率族蛋白A2抗体 规格：0.1ml/0.2ml支 产品应用：WB ELISA IHC-P IHC-F Flow-Cyt ICC IF Anti-HMGB1 (High Mobility Group Box protein 1)高迁移率族蛋白-1抗体 规格：0.1ml/0.2ml支 产品应用：WB ELISA IHC-P IHC-F Flow-Cyt ICC IF Anti-HO-1/HSP32 (Hemeo xygenase 1)血红素氧合酶 ...
WebNov 7, 2013 · High-mobility group box 1 (HMGB1), as a member of the HMG family, has location-specific biological functions: within the nucleus as a DNA chaper-one, within the …
WebRNA聚合酶Ⅰ相关的转录分子UBF的DNA结合结构域是85个氨基酸残基的重复区，与HMG1和HMG2的A、B结构相似，所以这种特征性结构被命名为“HMG"结构域。 中文名称 HMG框 … can diabetics have sweet n lowWebHigh Mobility Group Protein Box-1 ELISA KIT. High Mobility Group Protein Box-1 ELISA KIT专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。完善的库存及供应体系以及高效稳定的纯化技术，保证 ... fish on wheelsWebHigh mobility group (HMG) transcription factors fall into one of three subfamilies. The HMGA subfamily shares AT-hook motifs, which are 9 amino acid segments that bind AT-rich DNA stretches in the DNA minor groove. The HMGB subfamily all contain an HMG Box, which is an 80 amino acid DNA-binding domain consisting of three alpha helices that fold ... can diabetics have tomatoesWebHigh mobility group box-1 protein (HMGB1) is an important inflammation factor, as well as a necessary and sufficient mediator of inflammation during sterile and inflect-associated response. Levels of HMGB1 in serum and tissues can reflect the severity of inflammation and tissue damage, and it is also closely related to the prognosis of diseases. fish on westport beach houseWebAmong the broad range of endogenous mediators of inflammation, high mobility group box 1 (HMGB1) is a classic example of an alarmin, that is a nuclear protein released to … can diabetics have white riceWebSep 2, 2024 · 2.6 调节微RNA（micro RNA，miRNA）和高迁移率族蛋白1（high-mobility group box-1，HMGB1）表达. miRNA是含18～25个核苷酸的单链非编码内源性分子，参与转录后基因表达的调节，致癌和抑癌基因miRNA的改变通常与肿瘤进展改变有关。 can diabetics receive kidney transplantsWebApr 9, 2024 · High mobility group A1 (HMGA1) protein and gene expression correlate with ER-negativity and poor outcomes in breast cancer. HMGA1 exacerbates tumor progression by activating miR-222 through PI3K/Akt/MMP-9 signaling pathway in uveal melanoma. fish on windows