Cftr inhibitory factor
WebApr 1, 2007 · The Δ F508-CFTR mutation, the most common gene mutation in cystic fibrosis (CF), results in diminished plasma membrane expression of CFTR, leading to loss of … WebMay 16, 2024 · Nevertheless, inhibition of CFTR with the CFTR inhibitor 172 promoted cell proliferation through reduced micro-RNA (miR)-125b, which acts as a tumor suppressor, decreasing the expression of matrix metalloproteinase 11 (MMP11), and vascular endothelial growth factor (VEGF) −A (p < 0.05) . Further, high levels of urokinase …
Cftr inhibitory factor
Did you know?
WebOct 14, 2016 · Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 19,20-EpDPE hydrolysis intermediate PDB DOI: 10.2210/pdb5TNF/pdb Classification: hydrolase/hydrolase inhibitor Organism (s): Pseudomonas aeruginosa UCBPP-PA14 Expression System: Escherichia coli Mutation … WebCFTR is a well-validated targeted for development of inhibitors for therapy of secretory diarrheas and activators for therapy in cystic fibrosis. Our lab has identified and …
WebCif is the first bacterial factor identified that inhibits TAP1 function and MHC class I antigen presentation VIrulence factors AprA (alkaline proteasae) and Cif (CF transmembrane conductance regulator inhibitory factor) perturb sodium and chloride transport and osmosis in … WebJul 16, 2024 · SRI-37240 induced concentration-dependent increases in CFTR-dependent (forskolin-stimulated and sensitive to the inhibitor CFTR Inh-172) ... Translation factors. Well-differentiated primary CFTR.
WebThe cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated Cl(-) channel expressed in various epithelial cells, and is a pharmacological target for … WebThe CFTR inhibitory factor is a protein virulence factor secreted by the Gram-negative bacteria Pseudomonas aeruginosa[1] and Acinetobacter nosocomialis.[2] Discovered at Dartmouth Medical School, Cif is able to alter the trafficking of select ABC transporters in eukaryotic epithelial cells, such as the cystic fibrosis transmembrane conductance …
WebJul 29, 2024 · Previous studies have shown that functional CFTR at the epithelial cell surface is critical for limiting NF-κB mediated cell signaling leading to IL-8 expression both at baseline and following activation with pro-inflammatory cytokines IL-1 and TNF-α (Perez et al., 2007; Vij et al., 2009), for inhibiting epidermal growth factor receptor (EGFR ...
WebNational Center for Biotechnology Information contractors hoover alWebJan 20, 2024 · 64 the CFTR Inhibitory Factor (Cif) from Pseudomonas aeruginosa [2]. 65. Cif is an epoxide hydrolase from . P. aeruginosa. that serves as a virulence factor . 66. in lung infections. Cif has been shown to decrease the concentration of the Cystic . 67. Fibrosis Transmembrane Conductance Regulator (CFTR) on the apical surface of lung . 68 contractors home warrantyWebThis virulence factor, named CFTR inhibitory factor (Cif), is regulated by a TetR-family, epoxide-responsive repressor known as CifR via direct binding and repression. We identified two sites of CifR binding in the intergenic space between cifR and morB, the first gene in the operon containing the cif gene. contractors home improvementWebJul 1, 2015 · The CFTR inhibitory factor (Cif) is an epoxide hydrolase (EH) virulence factor secreted by the bacterium Pseudomonas aeruginosa. Sequence alignments reveal a pattern of Cif-like substitutions that ... contractors hooksett nhWebJan 29, 2010 · CFTR is the ion channel responsible for chloride secretion into the airway surface liquid (ASL) in the lung. The removal of CFTR from the cell surface leads to reduced chloride efflux, ASL dehydration, and decreased mucociliary clearance, thus facilitating the establishment of a bridgehead for bacterial infection. contractors hot springs villageWebCFTR inhibitors The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a cAMP-regulated Cl- channel whose major function is to facilitate epithelial fluid … contractors hornell nyWebJun 2, 2024 · The CFTR inhibitory factor (Cif) is a protein virulence factor secreted by the Gram-negative bacteria Pseudomonas aeruginosa and Acinetobacter nosocomialis.Discovered at Dartmouth Medical School, Cif is able to alter the trafficking of select ABC transporters in eukaryotic epithelial cells, such as the cystic fibrosis … contractors hillman mi